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Migraine and Medical Cannabis

Migraine is more than just a condition characterised by headaches. People with migraine experience repeated episodes of intense, throbbing pain that affects daily living. These chronic attacks can last for hours or even days, often accompanied by other symptoms, such as nausea or sensitivity to light.

When standard therapies are insufficient, medical cannabis may be prescribed to some patients as part of a wider treatment plan.

Migraine and Medical Cannabis: The Facts

50%

decrease in self-reported headache and migraine severity after cannabis use [1]

10 million
adults in the UK are estimated to be affected by migraine [2]

What are the Symptoms of Migraine?

The main symptom is an intense headache described as a throbbing pain on one side of the head. In children, the pain is more commonly felt on both sides. The pain may be moderate or severe and may worsen with movement.

Other symptoms include:

  • Feeling and/or being sick
  • Increased sensitivity to light and sound
  • A drop in concentration levels

Less common symptoms include:

  • Sweating
  • Temperature changes – feeling either too hot or too cold
  • Stomach pain
  • Diarrhoea

What are the Different Types of Migraine?

There are several different types of migraine. The symptoms can vary from person to person. Knowing which type of migraine you have can help you understand your symptoms and discuss them with your healthcare professional.

1. Migraine with aura – This type of migraine can cause temporary symptoms, known as an aura, which may happen before or during a migraine attack. These can include:

  • Visual disturbances, such as seeing flashing lights, dark spots or zigzag patterns.
  • Numbness or tingling sensations, similar to pins and needles, often starting in one hand and moving up the arm before affecting the face, lips or tongue.
  • Dizziness or a loss of balance and, in very rare cases, loss of consciousness.
  • Speech impairment.

2. Migraine without aura – This is a migraine that happens without the warning symptoms of an aura.

3. Migraine aura without headache (silent migraine) – This is when someone has the warning symptoms of a migraine aura, but does not develop a headache.

4. Abdominal migraine – This is often diagnosed in children. Instead of headaches, people have episodes of stomach pain, nausea and vomiting. People with abdominal migraine often have a personal or family history of migraine headaches.

What is Chronic Migraine?

Chronic migraine means having headaches on 15 or more days each month for more than 3 months. At least 8 of these days involve migraine symptoms. Chronic migraine can affect daily life and make everyday activities more difficult.

What is Episodic Migraine?

Episodic migraine refers to experiencing migraine on less than 15 days per month.

What Causes Migraine?

The exact cause of migraine is unknown. Migraine is thought to involve changes in brain activity that affect nerve signals, chemicals and blood vessels in the brain. These changes are temporary, which is why migraine symptoms come and go. Research also suggests that genetics may make some people more likely to experience migraine.

Many people with migraine notice things that seem to trigger their attacks. However, research into migraine triggers is mixed. For example, some studies suggest that craving certain foods may actually be an early symptom of migraine, rather than the food being a trigger.

Possible migraine triggers may include:

  • Hormones – changes in hormone levels around the time of a period may trigger migraine. Some women experience migraine shortly before, during or after a period. This is sometimes called ‘menstrual migraine’.
  • Emotions – stress, anxiety, tension, shock, depression or even excitement may trigger migraine.
  • Physical factors – lack of sleep, unusual working hours such as shift work, poor posture, tension in the neck or shoulders, jet lag, low blood sugar or starting a new exercise routine.
  • Diet – missing meals, eating at irregular times, dehydration, alcohol, caffeine or foods containing tyramine may be possible triggers.
  • Environmental factors – bright or flashing lights, flickering screens, smoking, loud noises, changes in humidity or very cold weather, strong smells such as perfume or aftershave, and poor air flow in a stuffy room or building.
  • Medicines – certain sleeping tablets, the combined oral contraceptive pill (COCP) and hormone replacement therapy (HRT) may be possible triggers.

Keeping a migraine diary can help you spot patterns in your migraine attacks and identify possible triggers.

How is Migraine Diagnosed?

There is no specific test to diagnose migraine. A GP will usually ask about your symptoms and medical history to look for patterns that may suggest migraine.

Tracking your migraine symptoms over time may help you understand what triggers your attacks. This may include:

  • Date and time
  • Headache location
  • Activities beforehand
  • Potential triggers, such as bright lights, strong smells or loud noises
  • Other symptoms or notable details

Blood tests or imaging scans may sometimes be needed to help rule out other possible causes of your headaches.

How Does Migraine Affect People?

Migraine can have a significant impact on everyday life. During an attack, symptoms such as severe pain and sensitivity to light or sound may make it difficult to go outside, work, exercise or carry out daily activities. As attacks can occur suddenly and triggers vary from person to person, their impact can also be difficult to predict.

Frequent or severe migraine may also affect sleep, energy levels and emotional wellbeing. Some people with migraine also experience insomnia, anxiety or depression.

When other treatments have not provided enough relief or are not suitable, a specialist may discuss other treatment options, including medical cannabis, as part of a personalised treatment plan.

You can visit our testimonials page to read real-life patient experiences with medical cannabis.

"Life before medical cannabis was isolating, it was painful and above all it was tiresome. I can't put into words how much medical cannabis has changed my life"
Hannah Curaleaf Clinic Patient

How is Migraine Treated?

There is no cure for migraine, but treatment can help manage symptoms and reduce the frequency or severity of attacks.

For a migraine attack, treatment may include painkillers such as paracetamol or ibuprofen or migraine medicines called triptans.

To help prevent migraine attacks, a doctor may prescribe treatments such as beta blockers, antidepressants or anti-seizure medicines, depending on the individual. The relatively recent development of calcitonin gene-related peptide inhibitors has provided additional promise for those who live with chronic migraine.

Cognitive behavioural therapy (CBT) and lifestyle changes may also help people identify potential triggers and manage their symptoms.

When standard treatments do not provide enough relief or are not suitable, medical cannabis may be considered as part of a patient’s wider treatment plan.

Migraine and Medical Cannabis

In the UK, medical cannabis can be prescribed by specialist doctors on the General Medical Council (GMC) Specialist Register. It may be considered when other treatments have not provided enough relief or have caused unwanted side effects.

A specialist doctor will assess each patient to see if medical cannabis may be suitable. They will look at their diagnosis, overall health and the treatments they have already tried. They will also consider which symptoms are still causing problems.

Research Regarding Medical Cannabis and Migraine

Although medical cannabis may be considered for some people with migraine in the UK, clinical research into its use remains limited. Medical cannabis for migraine has also received wider public attention, including coverage by the BBC.

The UK Medical Cannabis Registry, set up by Curaleaf Clinic in 2019, collects information from patients prescribed medical cannabis for a range of conditions, including migraine. This information helps researchers understand how patients respond to treatment over time.

Research Summary: Can Cannabis Help Migraine?

The latest UK Medical Cannabis Registry research on migraine, published in 2026, looked at 203 adults who had been prescribed medical cannabis for migraine [3]. Researchers looked at changes in how migraine affected daily life, as well as sleep, anxiety and overall quality of life. They also recorded side effects reported by patients.

During the study, researchers found that:

  • Average scores for how headaches affected daily life improved at each follow-up.
  • Overall quality of life improved, and patients reported less pain and discomfort.
  • At 24 months, around 39% of patients had a meaningful improvement in anxiety scores and around 47% had a meaningful improvement in sleep quality scores.

These findings add to the growing real-world evidence on medical cannabis and migraine. More research is needed to understand its potential role in treating migraine.

Side Effects of Medical Cannabis Reported by Patients with Migraine

During the study, 31 patients (15% of the group) reported a total of 249 side effects. The most common side effects were:

  • Headache
  • Dry mouth
  • Impaired concentration
  • Fatigue
  • Nausea
  • Tiredness (lethargy)

Headaches were reported as a side effect during medical cannabis treatment. However, the researchers noted that it was difficult to tell whether a headache was a side effect of the treatment or a symptom of the patient’s migraine.

Can I be Prescribed Medical Cannabis for Migraine?

Whether medical cannabis may be suitable will depend on each patient’s individual needs. A specialist doctor will consider their diagnosis, overall health, medicines they take and treatments they have already tried.

The first step is to complete Curaleaf Clinic’s online eligibility assessment. This initial check helps us understand whether a consultation may be appropriate. It does not guarantee that medical cannabis will be prescribed.

References

[1] Cuttler C, Spradlin A, Cleveland MJ, Craft RM. Short- and Long-Term Effects of Cannabis on Headache and Migraine. J Pain. 2020 May-Jun;21(5-6):722-730. doi: 10.1016/j.jpain.2019.11.001. Epub 2019 Nov 9. PMID: 31715263.

[2] The Migraine Trust (n.d.). Who is Living with Migraine in the UK? Available at: https://migrainetrust.org/wp-content/uploads/2021/08/State-of-the-Migraine-Nation-population-rapid-review.pdf

[3] Hooper L, Erridge S, Clarke E, McLachlan K, Coomber R, Iqbal A, Rucker JJ, Weatherall MW, Sodergren MH. UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine. Brain Behav. 2026 Apr;16(4):e71323. doi: 10.1002/brb3.71323. PMID: 41943196.

Table of Contents

Frequently Asked Questions about Migraine

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  • Take painkillers such as paracetamol, aspirin or ibuprofen as soon as possible.
  • Rest in a quiet, dark room and avoid anything that you think may make your symptoms worse.
  • Try eating something light if you feel it will help.
  • If these don’t work seek medical help from your doctor who may consider medications which can either help once a migraine begins or prevent them from starting altogether.

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The length of a migraine attack will vary from person to person. Without taking any medication, a headache may last anywhere from 4 to 72 hours. Painkillers are recommended at the very first signs of a migraine to reduce the symptoms and severity of an attack.

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Tension-type headaches are typically felt as a band of pain across the forehead rather than on one side of the head. Migraine pain is typically more severe than a tension-type headache, however this is not always the case. Other symptoms, such as nausea or vomiting, sensitivity to light and sound, and difficulty concentrating, can also occur with migraine and may help distinguish it from a tension-type headache.